Drivers are on full throttle for most of the lap due to its long straights and fast corners, and is usually the scenario in which the open-wheeled F1 cars show the raw speed they are capable of (372 kilometres per hour (231 mph) during the mid-2000s V10 engine formula, although in 2012 with the 2.4L V8 engines, top speeds in F1 rarely reach over 340 kilometres per hour (211 mph)). The circuit is generally flat, but has a gradual gradient from the second Lesmos to the Variante Ascari. Due to the low aerodynamic profile needed, with its resulting low downforce,[6] the grip is very low; understeer is a more serious issue than at other circuits; however, the opposite effect, oversteer, is also present in the second sector, requiring the use of a very distinctive opposite lock technique. Since both maximum power, and minimal drag is the key for speed on the straights, only competitors with enough power or aerodynamic efficiency at their disposal are able to challenge for the top places.[6]

In addition to Formula One, the circuit hosts an endurance event, the 1000 km Monza, which has been run as part of the World Sportscar Championship and the Le Mans Series. Monza also featured the unique Race of Two Worlds events, which attempted to run Formula One and United States Auto Club National Championship cars against each other, and previously held rounds of Grand Prix motorcycle racing, in the Italian motorcycle Grand Prix. Current major events are races of the World Touring Car Championship and the Superbike World Championship, as well as various local championship races.